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10th International ISSX Meeting
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Short Courses

Metabolomic Profiling as a Tool for Identifying Novel Drug-Target Interactions
Chair: David Wishart, University of Alberta, Edmonton, Canada

Model Systems and Methods for Assessing Uptake and Efflux of Small Molecules
Chair: Reina Bendayan, University of Toronto, Toronto, Canada

Strategies and Techniques for Predicting Human Drug Metabolism and Drug-Drug Interactions
Chairs: Uwe Fuhr, Uniklinik Koln, Koln, Germany; Olavi Pelkonen, University of Oulu, Oulu, Finland

Application of Mass Spectrometric Methods to Drug Metabolism and Pharmacokinetics
Chair: Ragu Ramanathan, QPS, Newark, Delaware, USA

Keynote Lecture

Systems Pharmacology – Systems Biology meets Drug Discovery & Development
Doug Lauffenburger, Massachusetts Institute of Technology, Cambridge, Massachusetts

Plenary Sessions

Drug-Metabolizing Enzymes as Potential Therapeutic Targets
Chair: Paul Hollenberg, University of Michigan, Ann Arbor, Michigan, USA

Utility of Genetic and Epigenetic Technologies in Drug Development and Safety Assessment
Chair: Ann Daly, Newcastle University, New Castle Upon Tyne, UK

Identification and Use of Novel Biomarkers for Xenobiotic-Induced Toxicity
Chair: David Riddick, University of Toronto, ON, Canada

Genetically Modified Animal Models for Predicting Human Drug Disposition and Response
Chair: Xinxin Ding, Wadsworth Center, Albany, NY, USA

Parallel Symposia

Nuclear Receptors as Regulators of Drug Metabolism and as Therapeutic Targets
Chair: Ulrich Zanger, IKP, Stuttgart, Germany

Pharmacogenomics and Personalized Medicine: Progress in Clinical Implementation
Chair: Rachel Tyndale, University of Toronto, Toronto, Canada

Regulation of Drug Transporter Expression and Function
Chair: Micheline Piquette-Miller, University of Toronto, Toronto, Canada

Application of Structural Biology to the Prediction of Drug Response, Metabolism and Toxicity
Chair: Jim Halpert, University of California, San Diego, California, USA

Metabolism, Pharmacokinetics and Interactions of Traditional Medicines and Natural Products
Co-Chairs: Chuan Li, SIMM, Shanghai, China;
Ge Lin, Chinese University Hong Kong, Hong Kong, China

Cell Type Specific Mechanisms of Adverse Drug Reactions
Chair: Michael Aleo, Pfizer, Groton, Connecticut, USA

Targeted Drug Delivery for Enhanced Therapy
Chair: Christine Allen, University of Toronto, Toronto, Canada

Use of PB-PK Modeling in Pharmaceutical Safety Assessment
Chair: Aleksandra Galetin, University of Manchester, Manchester, UK

Regulatory Perspectives in Drug-Drug Interactions and Metabolites in Safety Testing
Chair: Greg Slatter, Amgen, Seattle, Washington, USA

Toxicogenomic and Metabolomic Profiling: Current Status and Future Utility in Assessing Drug Efficacy and Safety
Chair: Tim Zacharewski, Michigan State University, East Lansing, Michigan, USA

Tissue Imaging and Distribution Studies in Drug Development
Chair: Yasuyoshi Watanabe, RIKEN Center, Kobe, Japan

Development and Uses of Hepatocyte-Derived and Hepatocyte-Like Cells for Predicting Human Drug Metabolism
Chair:  Martine Daujat-Chavanieu, INSERM, Montpellier, France

Meeting Organizing Committee

Denis Grant, Meeting Chair,  University of Toronto, Toronto, ON, Canada

  • Stelvio Bandiera, University of British Columbia, Vancouver, BC, Canada
  • Jack Bend, University of Western Ontario, London, ON, Canada
  • Chantal Guillemette, Laval University, Quebec, QC, Canada
  • Malle Jurima-Romet, Celerion, Montreal, QC, Canada
  • David K.H. Lee, InterVivo Solutions, Inc., Mississauga, ON, Canada
  • Tom Massey, Queen's University, Kingston, ON, Canada
  • Eddie Morgan,  Emory University, Atlanta, GA, USA
  • Sandy Pang University of Toronto, Toronto, ON, Canada
  • Allan Rettie, (SAC Member), University of Washington, Seattle, WA, USA
  • David Riddick, University of Toronto, Toronto, ON, Canada
  • Nathalie Rioux, Epizyme, Inc., Cambridge, MA, USA
  • Rachel Tyndale, University of Toronto, Toronto, ON, Canada
  • Peter Wells, University of Toronto, Toronto, ON, Canada

International Scientific Advisory Board (ISAB)

  • Ann Daly, Newcastle University, Newcastle Upon Tyne, United Kingdom
  • Patrick Dansette, Université Paris Descartes, Sorbonne Paris Cité, Paris, France
  • Xinxin Ding, Wadsworth Center, Albany, New York, USA
  • Uwe Fuhr, University Hospital of Cologne, Cologne, Germany
  • Ron Hines, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
  • Paul Hollenberg, University of Michigan Medical School, Ann Arbor, Michigan, USA
  • Richard Kim, University of Western Ontario, London, Ontario, Canada
  • Steve Leeder, Children's Mercy Hospital, Kansas City, Missouri, USA
  • Chuan Li, Shanghai Institute of Materia Medica, Shanghai, China
  • Peter Mackenzie, Flinders University School of Medicine, Adelaide, Australia
  • Larry Marnett, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
  • Urs Meyer, (Past President), Biozentrum, University of Basel, Basel, Switzerland
  • Deborah Nicoll-Griffith, Merck & Co., Rahway, New Jersey, USA
  • Frank Oesch, University of Mainz, Mainz, Germany
  • B. Kevin Park, University of Liverpool, Liverpool, United Kingdom
  • Olavi Pelkonen, University of Oulu, Oulu, Finland
  • Rory Remmel, University of Minnesota, Minneapolis, Minnesota, USA
  • A. David Rodrigues, Bristol-Myers Squibb, Princeton, New Jersey, USA
  • Glenn Sipes, University of Arizona College of Medicine, Tucson, Arizona, USA
  • Bill Smith, (President), Pfizer Inc. La Jolla Labs, San Diego, California, USA
  • Steve Tannenbaum, MIT, Cambridge, Massachusetts, USA
  • Ken Thummel, University of Washington, Washington, USA
  • Jacques Turgeon, Centre Hospitalier de L'Universite de Montreal, Montreal, Quebec, Canada
  • Donald J. Tweedie, Boehringer Ingelheim, Ridgefield, Connecticut, USA
  • Jack Uetrecht, University of Toronto, Toronto, Ontario, Canada
  • Yasushi Yamazoe, Tohoku University, Sendai, Japan
  • Uli Zanger, Dr. Margarete Fischer-Bosch Institute, Stuttgart, Germany


The 2013 R.T. Williams Distinguished Scientific Achievement Award is presented to an ISSX member or non-member from any region that has made substantial and seminal scientific contributions to the field over a sustained period. The focus of this award is the individual's scientific accomplishments and it is intended to recognize the best in the field internationally. The 2013 recipient is Yuichi Sugiyama, Ph.D., RIKEN Innovation Center, Research Cluster for Innovation, Saitama, Japan.

The 2013 Frederick J. Di Carlo Distinguished Service Award is presented to an ISSX member from any region with an illustrious record of important service to the Society and its goals.  The 2013 recipient is Robert P. Hanzlik, Ph.D.


We encourage all those involved in the fields of metabolism, pharmacology, toxicology, molecular biology and other related disciplines to consider submitting an abstract for a poster presentation at the 10th International ISSX Meeting to be held in Toronto, Ontario, Canada, September 29 - October 3, 2013. This meeting will provide a wonderful opportunity to showcase work being done in a variety of areas and to network with other researchers.

View all accepted meeting abstracts online.

Hotel Accommodations

Hotel rooms have been reserved at the Westin Harbour Castle Hotel at a special rate for ISSX attendees. Located 28 km from Pearson International Airport (YYZ), the hotel is easily accessible by airport shuttle, public transportation, taxi, and rental car.

  • Make reservations online through the special ISSX attendee hotel website at
  • If making reservations by phone at +1-800-937-8461, be sure to mention that you are an ISSX attendee to obtain the ISSX room rate. 

The Westin Harbour Castle, Toronto
1 Harbour Square
Toronto, M5J 1A6, Canada
(416) 869-1600  
Central Reservations: (800) 937-8461

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