Sunday, October 14, 2012

Note: All short courses will take place on Sunday, October 14, 2012

9:00 am - 12:15 pm | Short Course 1 : Integration of Pharmacokinetics-Pharmacodynamics (PK-PD) into the Drug Discovery & Development Process

Short Course Chair: David Rodrigues, Bristol-Myers Squibb, Princeton, NJ, USA

Speakers:

Robert Arnold, Auburn University, Auburn, AL, USA

Anjaneya Chimalakonda, Bristol-Myers Squibb Co., Pennington, NJ, USA

Amit Garg, Genentech Research and Early Development, South San Francisco, CA, USA

9:00 am - 12:15 pm | Short Course 2 : RNAi Therapeutics: A Primer on microRNAs and Their Regulatory Role in Regulation of Expression

Short Course Chair: Tsuyoshi Yokoi, Kanazawa University, Kanazawa, Japan 

Short Course Chair:  Yong Li, University of Louisville, Louisville, KY, USA

Speakers:

Amy Pasquinelli, University of California San Diego, La Jolla, CA, USA

Tsuyoshi Yokoi, Kanazawa University, Kanazawa, Japan

Yong Li, University of Louisville, Louisville, KY, USA

Nelson Chau, Regulus Therepeutics, San Diego, CA, USA

1:30 pm - 4:45 pm | Short Course 3 : Multi-Variate Kinetic Analyses for Drug Metabolizing Enzymes and Transporters; Combined in vitro Expression Systems; in silico; Optimizing Clinical Studies

Short Course Chair: Donald Tweedie, Boehinger Ingelheim, Ridgefield, CT, USA

Speakers:

Joe Bentz, Drexel University, Philadelphia, PA, USA

K. Sandy Pang, University of Toronto, Toronto, ON, Canada

Xin Cindy Zhang, Eli Lilly and Company, Indianapolis, IN, USA

Bill Atkins, University of Washington, Seattle, WA, USA

1:30 pm - 4:45 pm | Short Course 4 : Use of Tissue Imaging Techniques to Assess Drug Entry into Brain and/or into Tumors

Short Course Chair: Sonia de Morais, Abbott Laboratories, North Chicago, IL, USA

Speakers:

Roger Gunn, Imperial College of London, London, U.K.

Gary Siuzdak, The Scripps Research Institute, La Jolla, CA, USA

N. Harry Hendrikse, VU University Medical Center, Amsterdam, the Netherlands

Markus Stoeckli, Novartis Institutes of Biomedical Research, Basel, Switzerland

6:15 pm - 7:00 pm | Keynote Lecture 1 : New Mass Spectrometry Methods Including Laser Capture MS/MS

Richard Caprioli, Vanderbilt University, Nashville, TN, USA

7:30 pm - 9:30 pm | Opening Welcome Reception Sponsored by Life Technologies

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Monday, October 15, 2012

9:00 am - 11:00 am | Plenary Session 1 : Innovative MS Methods and Their Application to DMPK

Session Chair: F. Peter Guengerich, Vanderbilt University School of Medicine, Nashville, TN, USA

Speakers:

W. Griffith Humphreys, Bristol-Myers Squibb, Princeton, NJ, USA

Hendrick Neubert, Pfizer, Inc., Andover, MA, USA

Rosa Liberman, Massachusetts Institute of Technology, Cambridge, MA, USA

11:30 am - 12:30 pm | Society Awards

Presentation of the 2012 ISSX North American Scientific Achievement Award in Honor of Ronald W. Estabrook, and Sponsored by XenoTech, to R. Scott Obach, Ph.D.

Presentation of the 2012 ISSX North American Young Investigator Award, to Emily Scott, Ph.D.

 2:00 pm - 4:00 pm | Symposium 1 : Non-P450 dependent Oxidation Reactions

Session Chair: Bernd Clement, Christian-Albrechts University Kiel, Kiel, Germany

Speakers:
Bernd Clement, Christian-Albrechts University Kiel, Kiel, Germany

Alex Odermatt, University of Basel, Basel, Switzerland

Vasilis Vasiliou, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

2:00 pm - 4:00 pm | Symposium 2 : Disposition of Protein Conjugates

Session Chair: Anthony J. Lee, Abbott Laboratories, North Chicago, IL, USA

Speakers:

Anthony J. Lee, Abbott Laboratories, North Chicago, IL, USA

Mauricio Leal, Pfizer, Pearl River, NY, USA

Xiuxia Sun, ADC Biochemistry, Waltham, MA, USA

Ben Shen, Genentech, South San Francisco, CA, USA

4:30 pm - 6:30 pm | Symposium 3 : Novel Aspects of UDP-Glycosyl-Transferases

Session Co-Chair: Peter Ian Mackenzie, Flinders University School of Medicine, Australia

Session Co-Chair: Miki Nakajima, Kanazawa University, Kanazawa, Japan

Speakers:
Peter Ian Mackenzie, Flinders University School of Medicine, Australia

Miki Nakajima, Kanazawa University, Kanazawa, Japan

Anna Radominska-Pandya, University of Arkansas for Medical Science, Little Rock, AR, USA

4:30 pm - 6:30 pm | Symposium 4 : Novel Approaches to Study Transporters

Session Co-Chair: Hiroyuki Kusuhara, University of Tokoyo, Tokoyo, Japan

Session Co-Chair: Mary Vore, University of Kentucky, Lexington, KY, USA

Speakers:

Hiroyuki Kusuhara, University of Tokoyo, Tokoyo, Japan

Mary Vore, University of Kentucky, Lexington, KY, USA

Michael Gottesman, National Cancer Institute, Bethesda, MD, USA

John Schuetz, St. Jude Children's Research Hospital, Memphis, TN, USA

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Tuesday, October 16, 2012

 

9:00 am - 9:45 am | Keynote Lecture 2 : Addressing the Mechanism of Clinical Drug Toxicity using Animal Models and Metabolomics

Frank Gonzalez, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

10:15 am - 12: 15 pm | Symposium 5 : Disease Associated Genomic Variants of P450 Reductase and Steroid Hydroxylase P450s

Session Chair: Michael R. Waterman, Vanderbilt University School of Medicine, Nashville, TN, USA

Speakers:

Michael R. Waterman, Vanderbilt University School of Medicine, Nashville, TN, USA

Bettie Sue Masters, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA

Walter Miller , University of California San Francisco School of Medicine, San Francisco, CA, USA

Emily E. Scott, University of Kansas, Lawrence, KS, USA

Evan R. Simpson, Prince Henry's Institute, Clayton, Victoria, Australia

10:15 am - 12:15 pm | Symposium 6 : Clinical Focus: Underlying Mechanism of Hyperbilirubinemia

Session Chair: Donald Tweedie, Boehinger Ingelheim, Ridgefield, CT, USA

Speakers:

Evita van de Steeg, TNO, Utrecht, the Netherlands

Maarten Huisman, Johnson & Johson, Brussels, Belgium

Robert Tukey, University of California San Diego, La Jolla, CA, USA

1:30 pm - 3:30 pm | Symposium 7 : Novel Functions of Glutathione Trensferases

Session Chair: C. Roland Wolf, University of Dundee, Dundee, Scotland, UK

Speakers:

C. Roland Wolf, University of Dundee, Dundee, Scotland, UK

Philip Board, Australia National University, Canberra, , Australia

Danyelle M. Townsend, Medical University of South Carolina, Charleston, SC, USA

1:30 pm - 3:30 pm | Symposium 8 : Industrial Focus: DMPK Studies Using Modeling and Simulation

Session Chair: Sonia de Morais, Abbott Laboratories, North Chicago, IL, USA

Speakers:

Stephen Johnson, Bristol-Myers Squibb R&D, Princeton, NJ, USA

Mohamad Shebley, Abbott Laboratories, Abbott Park, IL, USA

Stefan Steyn, Pfizer, Inc., Groton, CT, USA

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Wednesday, October 17, 2012

 

9:00 am - 9:45 am | Keynote Lecture 3 : Drug Development of Biologics Beyond Antibodies

Naren Chirmule, Amgen, Thousand Oaks, CA, USA

10:15 am - 12:15 pm | Plenary Session 2 : Advances in the Development of Antibody Drug Conjugates as Therapeutics

Session Chair: Bill Smith, Pfizer, Inc., La Jolla Labs, San Diego, CA, USA

Speakers:

Alison M. Betts, Pfizer, Inc., Groton, CT, USA

Sandhya Girish, Genentech, South San Francisco, CA, USA

Beth Hinkle, Amgen, Inc., Thousand Oaks, CA, USA

Robert Lyon, Seattle Genetics, Bothell, WA, USA

1:30 pm - 2:15 pm | Keynote Lecture 4 : Chemical Perturbation of Codon Selection for tRNA

Peter Dedon, Massachusetts Institute of Technology, Cambridge, MA, USA

2:15 pm - 4:15 pm | Plenary Session 3 : Genes and Drugs

Session Chair: Ron Hines, Medical College of Wisconsin, Milwaukee, WI, USA

Speakers:

Jatinder Lamba, University of Minnesota, Minneapolis, MN, USA

Adam S. Gordon, University of Washington, Seattle, WA, USA

Alan R. Shuldiner, University of Maryland School of Medicine, Baltimore, MD, USA

Stephen P. Spielberg, U.S. Food and Drug Administration, Silver Springs, MD, USA

6:00 pm - 9:00 pm | Round Up Party at Eddie Deen's Ranch

Shuttles will depart from Hilton Anatole (Chantilly Entrance) at 6:00 pm

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Thursday, October 18

9:30 am - 11:30 am | Symposium 9 : Advances in Protein Adducts Technology: Dedicated to Sidney Nelson, Ph.D.
Session Chair: Paul Hollenberg, University of Michigan, Ann Arbor, MI, USA

Speakers:

Paul Hollenberg, University of Michigan, Ann Arbor, MI, USA

Daniel C. Liebler, Vanderbilt University School of Medicine, Nashville, TN, USA

Dennis R. Peterson, Anschutz Medical Campus, Aurora, CO, USA

9:30 am - 11:30 am | Symposium 10 : Industrial Focus: Nanotechnology and Disease: Drug and Gene Delivery

Session Co-Chair: Anna Radominska-Pandya, University of Arkansas, Little Rock, Little Rock, AR, USA

Session Co-Chair: Russell Prough, University of Louisville, School of Medicine, Louisville, KY, USA

Speakers:

Alexandru S. Biris, University of Arkansas, Little Rock, Little Rock, AR, USA

Vinod Labhasetwar, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA

Kam W. Leong, Duke University, Durham, NC, USA

Omid C. Farokhzad, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA

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Sidney D. Nelson Commemorative Symposium

October 18, 2012

1:00 pm - 5:30 pm

Anatole Hotel, Dallas, Texas

Please join us at the Hilton Anatole Dallas Hotel, Dallas on Thursday, October 18, 2012 to   commemorate the scientific career of the late Professor Sidney (Sid) D. Nelson.

A special symposium, Reactive Metabolites and Toxicity, will be held that day as an adjunct to the 18th North American Regional Meeting of ISSX in Dallas, Texas, Oct 14-18, 2012 (visit this page for program information).

The Nelson commemorative symposium is scheduled to follow on from an ISSX symposium chaired earlier that Thursday morning, October 18, by Prof. Paul Hollenberg as part of the regular ISSX scientific program.

There is no registration fee for attending the Nelson commemorative symposium, and ISSX is offering a special one-day registration rate for those interested in participating in more of the ISSX meeting.

Organizing Committee

• Allan Rettie (University of Washington, Seattle, WA)
• Cyrus Khojasteh (Genentech Inc., San Francisco, CA)
• Mingshe Zhu (Bristol-Myers Squibb, Princeton, NJ)
• Weichao Chen (Vertex Pharmaceuticals, San Diego, CA)
• Tom Baillie (University of Washington, Seattle, WA)
• Claire Forster (University of Washington, Seattle, WA)

Symposium Title

Reactive Metabolites and Toxicity

Speakers and Titles

Chairs: Allan Rettie and Cyrus Khojatesh

1:00 Allan Rettie (University of Washington, Seattle, WA) Welcome and Introductory Comments

1:10 Peter Moldeus (Karolinska Institute, Stockholm, Sweden): Sid’s Scandinavian Sabbaticals His Contributions to Research and Education

1:50 David Porubek (Oncogenex, Seattle, WA): Estrogen Biosynthesis and Catechol Estrogen Metabolites

2:30 Lance Pohl (NHLBI, Bethesda, MD): Role of Reactive Metabolites and the Innate and Adaptive Immune Systems in Drug-induced Liver Injury

3:10 Coffee Break

Chairs: Mingshe Zhu and Weichao Chen

3:30 Cyrus Khojasteh (Genentech Inc., South San Francisco, CA): Pennyroyal Oil Hepatotoxicity and the Role of Reactive Metabolites of Pulegone and Menthofuran

4:10 Peter Rademacher (Lawrence Berkeley National Labs, Berkeley, CA): Tienilic Acid and Its Positional Isomer: A Comparison of the Metabolism and Toxicity of an Intrinsic and an Immune-Mediated Hepatotoxin

4:50 Tom Baillie (University of Washington, Seattle, WA): Quinones, Quinoneimines, and Xenobiotic-Protein Adducts: Potential Mediators of Drug-Induced Toxicity

5:30 - 7:00 Reception