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Workshop Content and Schedule
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Sunday April 11, 2010 Registration
Noon – 5:00 p.m.
Short Course: Everything You Need to Know to Actively Participate in the Pharmacogenomics Workshop
1:00 p.m. - 4:00 p.m.
Introduction to Genetics and Cytochrome P450 Polymorphisms
Steven A. Wrighton, Ph.D.
Senior Research Fellow
Department of Drug Disposition
Lilly Research Laboratories
Lilly Corporate Center
Indianapolis, IN 46285
Phone: (317) 276-9219
Email: Wrighton_steven@lilly.com
Transporter Polymorphisms
Kathleen Hillgren, Ph.D.
Research Advisor
Department of Drug Disposition
Lilly Research Laboratories
Lilly Corporate Center
Indianapolis, IN 46285
Phone: (317) 433-6678
Email: k_hillgren@lilly.com
Advanced Polymorphisms; Copy Number Variants, Splice Variants, and Haplotypes
Yingying Guo-Avrutin, Ph.D.
Research Scientist
Department of Drug Disposition
Lilly Research Laboratories
Lilly Corporate Center
Indianapolis, IN 46285
Phone: (317) 277-4324
Email: guoying@lilly.com
Welcome Reception
5:00 p.m. - 7:00 p.m.
Monday April 12, 2010
Registration
7:00 a.m. – 10:00 a.m.
Posters Set Up
7:00 a.m. – 8:30 a.m.
Keynote Speaker
Magnus Ingelman-Sundberg
Genetic Variability of Drug Disposition: From Polymorphisms to Biomarkers
8:30 a.m. - 9:30 a.m.
Morning Session (45 min talks with 15 min break)
Genotype-Phenotype Relationships
9:30 a.m. - 12:45 p.m.
Chair: J. Steven Leeder, PharmD, Ph.D.
Division of Clinical Pharmacology and Medical Toxicology
Children’s Mercy Hospitals and Clinics
2401 Gillham Road
Kansas City, MO 64108
Phone: (816) 234-3088
Fax: (816) 855-1958
Email: sleeder@cmh.edu
Wolfgang Sadee, Dr.rer.nat.
Professor and Chair
Department of Pharmacology
Director, OSU Program in Pharmacogenomics
College of Medicine
The Ohio State University
Columbus OH 43210-1239
Phone: (614) 292 5593
Fax: (614) 292 7232
Email: wolfgang.sadee@osumc.edu
Insights into the Complexity of CYP2D6 Genotype-Phenotype Relationships
Andrea Gaedigk, Ph.D.
Manager, Pharmacogenetics Laboratory
Division of Clinical Pharmacology and Medical Toxicology
Children’s Mercy Hospitals and Clinics
2401 Gillham Road
Kansas City, MO 64108
Phone: (816) 234-3088
Fax: (816) 855-1958
Email: agaedigk@cmh.edu
Cholesterol Biosynthesis Pathway Genotypes and Statin Response Phenotypes
Ronald Krauss, M.D.
Senior Scientist and Director, Atherosclerosis Research,
Children's Hospital Oakland Research Institute
5700 Martin Luther King Jr Way
Oakland, California 94609
Phone: (510) 450-7600
Fax: (510) 450-7910
Email: rkrauss@chori.org
Genotype-Phenotype Associations in ADME Genes: Role of Epigenetics
Magnus Ingelman-Sundberg, Ph.D.
Professor, Pharmacology and Toxicology
Karolinska Institutet
SE-171 77 Stockholm
Sweden
Phone: +46 8-524 800 00
Fax: +46 8-31 11 01
Lunch and Posters (Posters up for through lunch second day)
12:45 p.m. - 1:30 p.m. Afternoon Session (45 min talks with 15 min break)
Clinical Consequences of Pharmacogenomics
1:30 p.m. - 4:45 p.m.
Chair: Richard Kim
Professor of Medicine, Physiology & Pharmacology
Division of Clinical Pharmacology
University of Western Ontario
Room A-LL-152, LHSC-University Hospital
339 Windermere Road
London, ON N6A 5A5 Canada
Phone: (519) 663-3553
Fax: (519)-663-3232
E-mail: Richard.Kim@Lhsc.on.ca
Clinical Validation and Utility of CYP Enzyme PGx
David Flockhart, M.D.
Professor of Medicine, Genetics and Pharmacology
Chief, Division of Clinical Pharmacology
Indiana University School of Medicine
1001 West 10th Street
Indianapolis, Indiana 46202
Tel: (317) 630-8795
Fax: (317) 630-8185
E-mail: dflockha@iupui.edu
Pharmacogenomics, Pharmacometabolomics and Delivery of Optimal Drug Therapy
Richard Kim, M.D.
Professor of Medicine, Physiology & Pharmacology
Division of Clinical Pharmacology
University of Western Ontario
Room A-LL-152, LHSC-University Hospital
339 Windermere Road
London, ON N6A 5A5 Canada
Phone: (519) 663-3553
Fax: (519)-663-3232
E-mail: Richard.Kim@Lhsc.on.ca
Applying PGx to Predict Risk vs Benefit for Drugs in Development
Leonardo Sahelijo, M.D.
Director Pharmacogenomics
TGRD Biological Sciences
LF4210, 675 North Field Drive,
Lake Forest, IL 60045
Tel.: (847) 582-3876
Fax: (224) 554-7933
E-mail: lsahelijo@tgrd.com
Statin Transporters in Liver and Muscle: New Insights to Statin-Induced Muscle Injury
Rommel G. Tirona, Ph.D.
Assistant Professor
Division of Clinical Pharmacology
University of Western Ontario
Room BLL-112, LHSC-University Hospital
339 Windermere Road
London, ON N6A 5A5 Canada
Phone: (519) 685-8500 ext 32102
Fax: (519)-663-3232
E-mail: Rommel.tirona@schulich.uwo.ca
Posters
4:45 p.m. - 6:00 p.m. Tuesday April 13, 2010
Industry Supported Symposium Breakfast - Sponsored by BioReliance
7:00 a.m. – 8:00 a.m.
Morning Session (45 min talks with 15 min break)
Drug Disposition PGx: Bridging the Gap from Pharmacokinetics to Clinical Utility
8:30 a.m. – 11:45 a.m.
Chair: Ken Thummel, University of Washington
Professor and Chair, Department of Pharmaceutics
Box 357610
H-272N, Health Sciences Center
University of Washington
Seattle, WA 98195-7610
Phone: (206) 543-0819
Fax: (206) 543-3204
Email: Thummel@u.washington.edu
Evidence Requirements for Pharmacogenomic Testing
David Veenstra, PharmD, Ph.D.
Associate Professor, Department of Pharmacy
Box 357630
H-375J, Health Sciences Center
University of Washington
Seattle, WA 98195-7630
Phone: (206) 221-6936
Fax: (206) 299-9303
Email: veenstra@u.washington.edu
Thienopyridines and Variation in Cytochrome P450 Genes: Pharmacokinetics, Pharmacodynamics, and Clinical Outcomes
William L. Macias, MD, Ph.D.
Senior Advisor
Lilly Research Laboratories
Lilly Corporate Center
Indianapolis, IN 46285
Phone: (317) 433-9492
Email: skirkwood@lilly.com
From Clinical Utility to Clinical Effectiveness: A Real World Perspective on Pharmacogenetics in Clinical Practice
Felix W. Frueh, Ph.D.
Vice President, R&D Personalized Medicine Medco Health Solutions, Inc. 7315 Wisconsin Avenue, Suite 1050E Bethesda, MD 20814 Phone: (240) 839-8374 Fax: (301) 771-2660 Email: felix_frueh@medco.com Regulatory Perspective on Pharmacogenetic Tests Informing Clinical Decisions
Shiew-Mei Huang, Ph.D. Deputy Director, Office of Clinical Pharmacology Center for Drug Evaluation and Research Food and Drug Administration CDER Office Building 51, Rm 3188, White Oak 10903 New Hampshire Avenue
Silver Spring, MD 20993 Phone: (301) 796-1541 Fax: (301) 847-8720 Email: shiewmei.huang@fda.hhs.gov Lunch and Posters
11:45 a.m. - 1:30 p.m. Afternoon Session: (45 min talks with 15 min break)
Emerging Issues in Drug Disposition Pharmacogenomics
1:30 p.m. – 4:45 p.m.
Chair: Erin G. Schuetz, Saint Jude Children’s Hospital, Memphis, TN, USA
Using Molecular Network Data from Human Liver to Model Hepatic ADME Regulation
Andrew Kasarskis, Ph.D.
Sage Bionetworks
1100 Fairview Avenue N, MS M2-829 Seattle, WA 98109
Email: akasarskis@gmail.com
The Not So Silent Polymorphisms
Erin G. Schuetz, Ph.D.
Saint Jude Children’s Research Hospital
262 Danny Thomas Place
Room I5303 Chili Care Center
Memphis, TN 38105
PH: (901) 595-2205
Fax: (901) 595-3125
Email: erin.schuetz@stjude.org
The SOPHIE Study Experience and Analysis of Transporter Expression to Enable Personalized Medicine
Kathleen Giacomini, Ph.D.
Professor and Co-Chair
Department of Bioengineering and Therapeutic Sciences Schools of Pharmacy and Medicine University of California San Francisco 1550 4th Street, Box 2911 San Francisco, CA 94143-2911 Tel: (415) 476-1936 Fax: (415) 514-4361 Email: kathy.giacomini@ucsf.edu Pharmacogenomics Research: A View from the NIH
Rochelle Long, Ph.D.
NIGMS, NIH
45 Center Dr., Rm. 2AS-49G Bethesda, MD 20892-6200 tel: (301) 594-3827 fax: (301) 480-2802 Email: rochelle_long@nih.gov Closing
4:45 p.m.
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