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Rabi S. Bhatta Dr.
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Last updated: 11/1/2016
Rabi Sankar Bhatta Dr.
Designated Country Member

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CSIR-Central Drug Research Institute
10/1, Jankipuram Extn,
Sitapur Road
226021  India
 [ Map ]
91 9721719603 (Phone)
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  ADME In Vitro, Animal Models, Bioactivation, Bioanalysis, Bioavailability, Biotransformation, Blood-Brain Barrier, Cyp Enzymes, Drug Absorption, Drug Delivery, Drug Discovery, Drug-Drug Interaction, Enzyme Induction, Enzyme Inhibition, In Silico Prediction, In Vitro/In Vivo Correlation, Mass Spectrometry, Pharmacokinetics, Phase 2 Metabolism, PK-PD, Reactive Drug Metabolites, Structure-Metabolism, Toxicokinentics
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Experience: 12 years
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• Bioanalytical and Analytical Method Development :
Development of bioanalytical and analytical method using HPLC and LC-MS/MS platform for estimation of NCE’s, drugs, metabolites, peptides etc in different biological matrices and formulations as by regulatory guidelines such as US-FDA, ICH etc.

• Clinical and Preclinical Pharmacokinetic Studies
Regulatory pharmacokinetic and toxicokinetic studies of NCE’s. Estimation pharmacokinetic parameters, bioavailability, dose-proportionality, gender variation, inter-species comparison, tissue distribution characteristics, excretion studies etc.

• In-vitro Metabolism, Metabolite Identification and Drug-Drug Interaction
In-vitro-In-vivo Extrapolation (IVIVE) for prediction of human clearance. Elucidation of metabolism pathway of NCE’s, metabolite identification. Drug-drug, herb-drug and food-drug interaction studies.

• Biopharmaceutics Permeability/Absorption characterization Studies across Caco-2, MDCK cell line, inverted gut sac method and in situ rat model. Protein binding and simulated gastro-intestinal stability for NCE’s/drugs. In-vitro-In-vivo correlation (IVIVC)

• Drug Delivery Designing formulation for NCE’s, ocular drug delivery.
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