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Last updated: 7/22/2017
Student/Postdoc in Training Member

Professional Information
University College of Medical Sciences & GTB Hospital (Delhi University)
Room no. 122, Multidisciplinary Research Unit,
UCMS& GTB hospital, Dilshad Garden
East Delhi
110095  India
 [ Map ]
91 9899983076 (Phone)
  Post Doctoral Fellow
  Bioactivation, Biomarkers, Biotechnology, Biotransformation, Cyp Enzymes, In Vitro/In Vivo Correlation, Toxicity
Personal Information
Additional Information
Ph.D. thesis work involved extensive research on studying toxicogenomics approach and gene-environment interaction analysis in chronic kidney disease of unknown etiology (CKDU) and also evaluated the role of pesticides in induction of cytotoxicity, DNA damage and apoptosis in PBMCs following pesticide exposure in in vitro study. Major strength includes working experience in gene-environment interaction, toxicology, biochemistry, cell culture, molecular biology. Now, In my Post Doctoral work,I am studying to find out whether agrochemicals (mainly various classes of pesticides and heavy metals) exposure on human renal proximal tubular cells with reference to fibrosis through the evaluation of apoptosis, epithelial-to-mesenchymal transition and signaling pathways involved. Also assessing the effects of various potential therapeutics (like renoprotective drugs, neutraceuticals and new generation anti-fibrotic substances) in ameliorating agrochemical-mediated renal dysfunction in vitro.
Social/Volunteer Organizations
More Information
I have published 6 paper in peer reviewed International Journal with good impact factor.
•Manushi Siddharth, Sudip K Datta, Savita Bansal, Md. Mustafa, Basu D. Banerjee, Om. P. Kalra, Ashok K. Tripathi. Study on Organochlorine Pesticide Levels in Chronic Kidney Disease Patients: Association with Estimated Glomerular Filtration Rate and Oxidative Stress. J Biochem Mol Toxicol 2012; 26:241-247. (I.F-1.59)
•Manushi Siddarth, Sudip K Datta, Basu D Banerjee, Om P Kalra, Ashok K Tripathi. Association of CYP1A1 polymorphism with chronic kidney disease: a case control disease. Environ Toxicology and Pharmacol, 2013; 16:164-170. (I.F.-2.00)
•Manushi Siddarth, Sudip K Datta, MD. Mustafa, Om P Kalra, Basu D Banerjee, Ashok K Tripathi. Increased level of organochlorine pesticides in chronic kidney disease patients of unknown etiology: role of GSTM1/GSTT1 polymorphism. Chemosphere 2014; 96:174-179. (I.F-3.34)
•Savita Bansal, Manushi Siddarth, Diwesh Chawla, Basu D Banerjee, S.V. Madhu and Ashok K. Tripathi. Advanced glycation end products enhance reactive oxygen and nitrogen species generation in neutrophils in vitro. Mol Cell Biochem 2011; 361:289-296. (I.F.- 2.32)
• Savita Bansal, Diwesh Chawla, Manushi Siddarth, Basu D Banerjee, S.V. Madhu and Ashok K. Tripathi. A study on serum advanced glycation end products and its association with oxidative stress and paraoxonase activity in type 2 diabetic patients with vascular complications. Clin Biochem 2013; 46: 109-114. (I.F.-2.45)
•Rishila Ghosh, Manushi Siddarth, Neeru Singh, Pawan Kumar Kare, Basu Dev Banerjee, Neelam Wadhwa, Ashok Kumar Tripathi. Organochlorine pesticide-mediated induction of NADPH oxidase and nitric oxide synthase in endothelial cell. JCDR 2017; 11 (1), BC09 (I.F.0.3)
•Rishila Ghosh, Manushi Siddarth, Neeru Singh, Vipin Tyagi, Pawan Kumar Kare, Basu Dev Banerjee, Om Prakash Kalra, Ashok Kumar Tripathi. Organochlorine pesticide level in patients with chronic kidney disease of unknown etiology and its association with renal function. Environmental Health and Preventinve Medicine, 2016. (Revision). (I.F.- 1.2)
•Manushi Siddarth, Savita Bansal, Basu D. Banerjee, Om. P. Kalra, Ashok K. Tripathi. Organochlorine pesticides induced oxidative stress mediated DNA damage in peripheral blood mononuclear cells. Toxicol In vitro 2016 (Communicated). (I.F.- 2.90)
•Manushi Siddarth, Basu D. Banerjee, Om. P. Kalra, Ashok K. Tripathi. Impact of GSTM1/ GSTT1 polymorphism and environmental exposure of organochlorine pesticides on oxidative stress biomarkers in chronic kidney disease patients. Chemosphere 2016 (Communicated). (I.F.- 3.34)
•Savita Bansal, Manushi Siddarth, Basu Dev Banerjee, Sri Venkata Madhu, Ashok Kumar Tripathi. Advanced glycation end products induced reactive species generation, DNA damage and apoptosis in endothelial cells in vitro. Int J Biochem and Cell Biol 2016 (Communicated) (I.F.-3.9)
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