Short Course 3: Quantifying the in vivo Activity of Human Drug Metabolizing Enzymes and Transporters
Chairs: Uwe Fuhr and Thomas Ebner

Kleiner Saal
13:30 - 17:00 | Monday, 26 June, 2017

All Short Course attendees are invited to a Short Course Attendee Lunch from 12:30 - 13:30 in the Kleiner Saal.


Select the links below to view and print the lecture slides. Please note, printed slides will not be provided.

13:30 - 13:45 | SC3.1. Current Approaches and Applications of Phenotyping Methods for Drug Metabolizing Enzymes and Transporters
Uwe Fuhr, University Hospital Cologne

13:45 - 14:10 | SC3.2. Endogenous Bile Acid Metabolites as Biomarkers for CYP3A
Tommy B. Andersson, AstraZeneca

14:10 - 14:35 | SC3.3. Detection of Novel Biomarkers for Drug Metabolizing Enzymes and Transporters Using Global Metabolomics
Yvonne Lin, University of Washington

14:35 - 15:00 | SC3.4. Endogenous Biomarkers for Drug Transporters
Deanna Kroetz, University of California San Francisco

15:00 - 15:30 | Refreshment Break

15:30 - 15:55 | SC3.5. Probe Drug Cocktails to Assess Transporter Activity in Humans: Concept, Probe Selection and in vitro Evaluation
Thomas Ebner, Boehringer Ingelheim

15:55 - 16:20 | SC3.6. Pharmacokinetic Evaluation of Transporter Probe Drugs in vivo and their Combination in a Cocktail
Fabian Müller, Boehringer Ingelheim

16:20 - 16:45 | SC3.7. Microdosing, Limited Sampling Strategies, and Continuous Infusion of Substrates: Suitable Techniques to Improve Enzyme / Transporter Activity Assessment
Nico Hohmann, Ruprecht-Karls University Heidelberg

16:45 - 17:00 | SC3.8. Caveat: Validation and Limitations of Phenotyping Methods for Drug Metabolizing Enzymes and Transporters
Uwe Fuhr, University Hospital Cologne