Print Page   |   Sign In   |   Join ISSX
6th Asia Pacific Meeting Program
Share |

Friday, May 11, 2018

Short Courses/Workshops

9:00 - 17:00 - Registration

SC 1: 9:00 - 12:00 - Mechanistic PK/PD Modeling and Simulation: Steps to Become a BPK/QSP Modeler

Chairs: Yanyan Zhang  and Rukmini Kumar 


9:00 - 10:00 - 
Introduction to Mechanistic PK/PD Modeling and its Application in Drug R&D - The Use of PBPK in Decision Making During Regulatory Review

Jiansong Yang, (Mosim, Shanghai


10:00 – 11:00 - Overview of QSP and FDA Regulatory Outlook to QSP

Rukmini Kumar (Vantage Research, India) 


11:00 – 12:00 - General Equations to Construct the Systems Model, and MATLAB Simbiology Software Orientation

Yan-Yan Zhan & Yoshihisa Shitara (Sanofi Shanghai and Tokyo)

 

12:00 – 12:30  Panel discussion and Q&A


Lunch for Workshop Attendees and Faculty


SC 2:  13:00 - 16:00  - Application of PBPK Modeling in Drug Discovery and Development: Case Studies

 

13:00-13:45 - Application of Physiologically-based Pharmacokinetic Modeling and Simulation in Prediction of Human PK and Drug-drug Interactions 

Chuan Lu  (Sanofi US)


13:45 - 14:30 - Modeling and Simulation of Double Peaks in Dogs using a Modified PBPK Model-Mechanism Exploring  and Clinical Risk Evaluation 

Hongcan Ren (Hutchison Pharma, Shanghai)


14:30 - 15:15 - Application of PBPK Model Analysis to Oncology Drug Development

Noriko Okudaira (DAIICHI SANKYO, Japan)

 

15:15 - 16:00 - Discovery PBPK: How to Estimate the Expected Accuracy of ISIVE and IVIVE for New Chemical Entities

Michael B. Bolger (Simulation Plus, US)


16:00 - 16:30 - Panel Discussion and Q&A


17:30 - 19:00 - Career Development for Students and Young Scientists: A session with a select group from industry and academia discussion multiple topics including career paths, how to interview, and how to write a winning CV.

Tom Baillie, Su Zeng, Zhuohan Hu, Mike Sinz,  John Miners, Bill Smith,  Jasminder Sahi  


19:00 – 20:30 - Dinner for Workshop Attendees and Faculty


Saturday, May 12, 2018

8:30 - Opening Ceremony

  • Welcome by Meeting Chairs Su Zeng and Jasminder Sahi

  • Opening words by CSSX chair

  • Opening words by ISSX chair

Keynote Lectures:

Chairs: Su Zeng and Jas Sahi

 

9:00 – 9:50 - Targeted Covalent Drugs and the Promise of Personalized Medicine

Tom Baillie (University of Washington, USA)


9:50 - 10:40 - Cellular Pharmacokinetics and Pharmacokinetics for Intracellular Targeted Drug Evaluation

Guangji Wang (China Pharmaceutical University, China)


10:40 - 11:00 - Group Photo


11:00 - 12:00 - Poster session

12:00 - 13:00 - Industry Sponsored Sessions over Lunch


Session 1

13:30 - 17:00 - In Vivo Function and Regulation of Drug Transporters 

Chairs: Yuichi Sugiyama and Wooin Lee


13:30 – 14:00 - Use of “Extended Clearance Concept” to Predict Clinical Outcomes from In Vitro Metabolism and Transport Data: Focusing on the Transporters in the Liver

Yuichi Sugiyama (RIKEN Institute, Tokyo) 


14:00 - 14:30 - The Use and Abuse of Extended Clearance

Ayman El-Kattan (Pfizer, USA)


15:00 - 15:15 - Coffee Break


Chairs: Yuichi Sugiyama &  Hua Li

14:30 - 15:00 - Time-dependent and Long-lasting Inhibition of OATP Transporters

Yoshihisa Shitara (Sanofi, Tokyo)

 

15:15 – 15:45 - Complexity and Diversity in SLCO Transporters, via Epigenetic and Splicing Regulation 

Wooin Lee (Seoul National University, S.Korea)

 

15:45 – 16:15 - Role of P-glycoprotein in BBB Penetration and Respiratory Toxicity of Opioid Drugs

Hua Li (Academy of Military Medical Sciences, China) 

 

 16:15 - 16:30 - Young Speaker

 

 16:30 -16:45 - Gold Sponsor Speaker


16:45 - 17:15 - Panel Discussion and Q&A


Session 2

13:30 - 17:00  ADMET of Pharmaceuticals

Chairs: Bill Smith and Sylvia Zhao


13:30 - 14:00 - Implications of Human P450 Structures for Drug Design Concept 

Jim Halpert (University of Connecticut, USA)


14:00 - 14:30 - Utility of Transgenic Mice for Identification of Biomarkers and Metabolism-Mediated Toxicological Mechanisms

Xinxin Ding (University Albany, USA)

 

14:30 - 15:00 - From Enzymology to Human ADME: Case Study of a Disproportionate Metabolite

Bill Smith (Gilead, USA) 


15:00 – 15:15 - Coffee Break


Chairs:  Bill Smith and Genfu Chen

 

15:15 - 5:45 - Unraveling the Contribution of Aldehyde Oxidase to Drug Clearance: Getting Closer to an Elusive Parameter

Mike Zientek (Takeda, USA)


15:45 – 16:15 - MicroRNAs in the Regulation of DMPK

Yu Am (UC Davis, USA)


16:15 - 16:30 - Young Speaker


16:30 – 16:45 - Gold Sponsor Speaker


16:45 - 17:15 - Panel Discussion and Q&A


17:15 - 18:15 - Poster Session


18:15 - 20:00 - Welcome Reception


Sunday, May 13, 2018

 

Keynote Lecture

8:30 - 9:20 - Role of Transporters in Pharmacokinetics (PK)/Pharmacodynamics (PD )/Toxicodynamics (TD) 

Prof. Yuichi Sugiyama, RIKEN Institute Japan

Chair: Zhuohan Hu (RILD)


Session 3

9:30 -12:00 - Personalized Medicine - Roles of Omics and Disease States

Chairs:  John Miners & Min  Huang 


9:30 - 10:00 - Predictive Pharmacogenomic Biomarkers for Personalized Medicine Tomorrow

Magnus Ingelman-Sundberg (Karolinska Instuitute, Sweden) 


10:00  -10:30 - Pharmacogenomic of Drug-induced SCARs 

Wichittra Tassaneeyakul (Khon Kaen University, Thailand)


10:30 - 10:45 Coffee Break


10:45 - 11:15 - Omics-based Personalized Medicine

Min Huang (Sun Yat-sen University, China)

 

11:15 - 11:45 - The Role of the Kidney in Drug Metabolic Clearance: Renal Drug Metabolism and the Effects of Impaired Renal Function on Non-renal Drug Metabolic Clearance

John O. Miners (Flinders University, Australia)


11:45 - 12:00 - Young Speaker

 

 12:00 - 12:15 - Gold Sponsor Speaker


Session 4

9:30 -12:00 - Drug Interactions and Liver Injury

Chairs:  Mike Sinz &  Eric Chan


9:30 - 10:00  - Drug-drug Interactions: Enzyme Induction

Mike Sinz (BMS, India)


10:00 - 10:30 - PBPK-modeling of Complex DDIs between Rivaroxaban and Amiodarone

Eric Chan (National University of Singapore)


10:30 - 10:45 - Coffee Break


10:45 - 11:15 - Disease Effect on Liver Drug Metabolism

Wen Xie (Univ of Pittsburgh, USA


11:15 - 11.45 - Disruption of Mitochondria Glucose Oxidation Pathway Sensitizes Liver to Acute Injury

Li Wang (University of Connecticut, USA)


11:45 - 12:00 - Young Speaker


12:00 - 12:15 - Gold Sponsor Speaker


12:00 - 13:00 - Industry-Sponsored Sessions over lunch


13:00 - 14:00 - Poster Sessions


Session 5

13:00 - 15:30 - Drug Development in a Regulatory Environment

Chairs:  Dafang Zhong and Chuang Lu


14:00 - 14:30 - Safety Testing of Drug Metabolites During Drug Development

Alex Xu  (CFDA China)


14:30 - 15:00 - Clinical Trials using Radiolabeled Drugs: Guidance and Application

Dafang Zhong (Chinese Academy of Sciences


15:00 - 15:30 - How PBPK Modeling Can be Best Leveraged for Regulatory Submissions

Lu Chuang (Sanofi USA)


15:30 - 15:45 - Coffee Break


15:45 - 16:15 - Comparative Evaluation of Coproporphyrins I and III with other Endogenous Compounds as Markers of OATP Inhibition in Healthy Subjects

Hong Shen (BMS, USA)


16:15 - 16:30 - Young Speaker


Session 6

13:00 - 15:30ADMET of Herbal Medicine

Chairs: Ge Lin and  Chuan Li


14:00 - 14:30 - CYP-mediated Metabolic Activation and Pyrrole-protein Adduct Formation:  The Cause and Biomarker of Pyrrolizidine Alkaloid N-oxide-induced Herbal Hepatotoxicity

Ge Lin (Chinese University of Hong Kong)


14:30 - 15:00 - Metabolism-mediated Toxicities of Terpene Furanoids

Jiang Zheng (Shenyang Pharmaceutical University China) 


15:00 - 15:30 - Role of the Herbal Medicine in Drug Interactions: Perpetrator and Victim

Chuan Li (Chinese Academy of  Sciences, Shanghai)


15:30 - 15:45 - Coffee Break


15:45 - 16:15 - Bile Acids Catabolism and TCM Functional Regulation

Haipin Hao (China Pharamceutical University, Nanjing)


16:15 - 16:30 - Young Speaker


16.30 - 17.30 - Round Table Discussions

  • Discussion 1: Bionalysis of Biologics - Challenges and Triumphs (Tao Hong)

  • Discussion 2: How to Leverage Modeling to Bridge Asian PK Studies (Jiansong and Jing Yang)

  • Discussion 3: New FDA DDI Guidance (Mike Sinz and Bill Smith)

  • Discussion 4:  Impact of Recent CFDA Guidances on Drug Development (Alex Xu, Dafang Zhong, Sylvia Zhou)

17:30 - 18:15 - Awards for Best Abstracts and Young Speakers


18:30  Banquet

Monday, May 14, 2018

Sunrise Forum Session

Session 7

9:00 – 10:15 Evolving Topics in Drug Metabolism

Chairs: Lushan Yu  and Xiaomei Zhuang


9:00 - 9:25 - Application of Targeted Metabolomics and 16S Microbial Profiling in PK-PD Study of Herbal Medicines: Case study of Ginseng

Ru Yan (University of Macau)


9:25 - 9:50 - Relationship of Transcriptional Factors to the Expression and Activity of UGTs in Human Liver and Kidney: Co-expression Network Analysis

Lan Tang (Southern Medical University, China)


9:50 - 10:15 - Epigenetic Activation of the Drug Transporters in Cancer Cells

Lushan Yu (Zhejiang University, China)


Session 8

9:00 – 10:15 Drug Metabolism Mediated Efficacy and Adverse Effects

Chairs: Yong Hee Choi and Cai-sheng Wu


9:00 - 9:25 - Drug Interaction of Metformin and Scutellariae Radix in Mice

Young Hee Choi (Dongguk University, South Korea)

 

9:25 - 9:50 - Application of PBPK in Patient Treatment to Improve Efficacy

Xiaoqiang Xiang (Fudan University, China


9:50 - 10:15 -  
Regulation of Metabolizing Enzymes and Transporters via P53 and its Effect on Liver Toxicity

Huichang Bi (Sun Yat-sen University, China


10:15 - 10:30 - Coffee Break


Session 9

10:30 - 11:45Application of Advanced Drug Metabolism Models

Chairs:  Sandhya Mandlekar and Yan Yang


10:30 - 10:55 - Characterization and Application of Novel P450 Knockout Rat Models

Xin Wang (East China Normal University)


10:55 - 11:20 - Animal Models in the Prediction of Drug-drug Interaction Potential of New Chemical Entities

Sandhya Mandlekar (BMS in India)


11:20 - 11:45 
Development and Application of Specific Probes and Biosensors of Metabolizing Enzymes

Guangbao Ge (Shanghai University of Chinese Medicine)


Session 10 

10:30 - 11:45Analytical Technology for ADME Studies of New Drug Platforms

Chairs:  Mingshe Zhu and Kenji Yahata


10:30 - 10:55 - Disposition of Cell Therapeutics: Analytical Strategy and Methods

Haifeng Song (Beijing National Proteomics Research Center)


10:55 - 11:20 - Direct Quantitation of Drugs in Organelles from Living Cell by Mass Spectrometry

Kenji Yahata (Sanofi Japan)


11:20 - 11:45 - Novel Approach for Study Of Exposure and Disposition of Herbal Medicines

Mingshe Zhu (MassDefect Technologies, USA)


11:45 - 12:00 - Closing Ceremony

  • Closing words by Zeng Su and Zhuohan Hu

  • Closing words by CSSX President

  • Closing words by ISSX President

Association Management Software Powered by YourMembership  ::  Legal