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ISSX Webinar: Drug Failures and Lessons for Future Drugs
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This webinar is now sold out. Please note that the recording will be available to all ISSX Members.


The presentation will survey the last 25 years of drugs withdrawn from the U.S. market. The reason for the withdrawal of the drug will be analysed under three broad categories of on target pharmacology, off target pharmacology with known receptor, and off target pharmacology with unknown receptor. The impact of these withdrawals will be related to drug discovery science and screening paradigms, to those relatively new to the area this gives an important historical rationale to some of the established practices. Reference will also be made to Phase 3 failures and whether these differ from drug withdrawals in underlying reasons. The session will close with a brief discussion of the factors and uncertainties that surround the decisions to remove drugs from the market or stop programs.


About the Speaker:

Dr. Dennis Smith worked in the pharmaceutical industry for 32 years after gaining his Ph.D. from the University of Manchester. During this period, he directly helped in the Discovery and Development of eight marketed NCEs. For the last nine years he has taken on a number of roles. Academic appointments include Honary Professor at the University of Capetown, where he is closely involved with H3D, the leading academic drug discovery unit in Africa. He is a member of a number of Expert Panels working within organisations such as Medicines for Malaria Venture and Cancer Research UK as well as serving on Scientific Advisory Boards for a number of Research Institutions. His research interests and publications span all aspects of Drug Discovery and Development particularly where drug metabolism knowledge can impact on the design of more efficacious and safer drugs. He has co-authored over 170 publications. He was recently elected as the first Fellow of the Drug Metabolism Discussion Group.

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