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Preliminary Meeting Program

Short Courses:  Sunday, October 19, 2014



9:00 am - 12:00 pm

Strategies and Tools for Drug-Drug Interaction Prediction
Co-Chairs: Shiew-Mei Huang, Ph.D., U.S. Food and Drug Administration (Invited); Takashi Izumi, Ph.D., Daiichi-Sankyo Co. Ltd.


Metabolite Biosynthesis and Quantitation by NMR Spectroscopy
Co-Chairs: R. Scott Obach, Pfizer Global Research and Development; Swapan Chowdhury, Takeda Pharmaceutical Company, Ltd.

1:00 pm - 4:00 pm

Non-CYP Metabolism in Drug Discovery
Co-Chairs: Teruko Imai, Kumamoto University, Jeffrey Jones, Washington State University


How to Maximize the Use of DMPK and Drug-Drug Interaction Data Available in the Literature and Regulatory Reviews during Clinical Development of New Chemical Entities
Co-Chairs: Nina Isoherranen, University of Washington; Yoshiyuki Shirasaka, Ph.D., Kanazawa University

Parallel Symposia
Monday, October 20, 2014



9:00 am - 11:30 am

Humanized and Knockout Animal Models in PK Studies
Co-Chairs: Hiroshi Yamazaki, Showa Pharmaceutical University; Robert Tukey, University of California


Cancer Biomarker Discovery
Co-Chairs: Sumio Ohtsuki, Kumamoto University; Frank Gonzalez, Center for Cancer Research, National Cancer Institute



2:00 pm - 4:30 pm

Chronopharmacological Strategy for Drug Discovery and Evolution
Co-Chairs: Shigehiro Ohdo, Kyushu University; Damjana Rozman, University of Ljubljana




Metabolomics in Drug Development and Drug Safety
Co-Chairs: Yoshiro Saito, National Institute of Health Sciences, Japan; Xiaochao Ma, University of Pittsburgh

Parallel Symposia
:  Tuesday, October 21, 2014

9:00 am - 11:30 am

Is Systems Biology a Powerful Tool to Explore/Understand the Mechanism of Action, Especially for Toxicity?
Co-Chairs: Hiroshi Suzuki, University of Tokyo; Ivan Rusyn, University of North Carolina


From Understanding to Prediction: Opportunities and Challenges in Modeling Xenobiotic Metabolism and Disposition
Co-Chairs: Yasushi Yamazoe, Food Safety Commission Cabinet Office, Government of Japan; Paul Ortiz de Montellano, University of California

3:00 pm - 5:30 pm

New Strategies in the Human CNS Barriers Research: The Development of New CNS Drugs and Therapies for the CNS Disorders
Co-Chairs: Hiroyuki Kusuhara, University of Tokyo; Xingrong Liu, Genentech, Inc.


Solving ADME/Tox Challenges in Drug Discovery
Co-Chairs: Toshiya Moriwaki, Takeda Pharmaceutical Company Limited; Cyrus Khojasteh, Genentech Inc.



Parallel Symposia
:  Wednesday, October 22, 2014

9:00 am - 11:30 am

Drug-drug Interactions: Novel Mechanisms and Advances in Prediction
Co-Chairs: Ikumi Tamai, Kanazawa University; Jane Kenny, Genentech, Inc.


Translational PKPD Modeling & Simulation in Front Line of Drug Development
Co-Chairs: Ryosei Kawai, Daiichi Sankyo Co. Ltd.; Shinji Yamazaki, Pfizer Inc.


Parallel Symposia
:  Thursday, October 23, 2014

9:00 am - 11:30 am

Personalized Drug Therapy: Promise and Challenge of a Genomics Approach
Co-Chairs: Miki Nakajima, Kanazawa University; Wolfgang Sadee, the Ohio State University


Frontier of Antibody Engineering for Next-generation Therapeutics, Including ADCs: Opportunities and Challenges
Co-Chairs: Masaki Ishigai, Chugai Pharmaceutical Co., Ltd.; Mauricio Leal, Pfizer

12:30 pm - 3:00 pm

Advances in PBPK Modeling and Simulation for Special Populations
Co-Chairs: Shinichi Inoue, Daiichi Sankyo Co., Ltd.; J. Steven Leeder, Children’s Mercy Hospital


Post-Translational and Transcriptional Regulation of Transporters and Metabolism
Co-Chairs; Ichiro Ieiri, Kyushu University; Xiaobo Zhong, Associate Professor, University of Connecticut

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