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ISSX Webinar: Quantitative Targeted Absolute Proteomics (QTAP): Methods and Applications for Studies
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Act fast! Limited seats are available. This webinar is free for ISSX Members. If you are not yet a member, select the link below to join ISSX. Your 2018 dues include immediate access to this member benefit.


About the Webinar:

The webinar will describe the development of quantitative targeted proteomic methods, the theory and limitations of the methods, options for standards used for quantification, and possible instruments that can be employed. Although quantitative proteomics can be applied to essentially any protein in biological systems, the emphasis and examples provided will be around applications for understanding drug disposition, i.e. proteins involved with ADME, such as CYPs, UGTs and transporters. 

Learning objectives: 
Following this webinar session, participants should:

  • Be able to describe alternative methods and approaches to QTAP
  •  List pros and cons of various LC-MS/MS platforms for QTAP
  •  Relay the theory and assumptions underlying QTAP and the possible errors in these measurements
  •  Restate where QTAP measurements of ADME proteins may provide insight and assistance in drug development or xenobiotic disposition.


About the Speaker:

Dr. Smith received a B.S. in Pharmacy from the University of Illinois, Chicago Medical Center, and then a Ph.D. in Pharmaceutical Chemistry, with an emphasis in pharmacokinetics, in 1985 from the University of California, San Francisco. After postdoctoral studies at the National Institutes of Health in Bethesda, MD, as a National Research Council Fellow, he joined the faculty of the College of Pharmacy at the University of Texas at Austin. In 1992 he moved to the School of Pharmacy at the University of North Carolina at Chapel where he is presently Associate Professor. Dr. Smith’s main research efforts are directed toward understanding factors influencing the disposition, pharmacokinetics, reactivity and potential toxicity of labile acyl glucuronide metabolites, the role of glucuronidation in intestinal toxicity of drugs and the modulation of drug glucuronidation by botanicals/herbal remedies. He is Director of the Quantitative Targeted Proteomics Laboratory which utilizes LC-MS for protein measurements in complex matrices.



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