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Workshop Program

 

Workshop Program

 

 

Thursday, December 12, 2019

9:00 - 9:45 AM

Overview - Basic Determinants for the Disposition/ADME of Protein Therapeutics

Joseph Balthasar, SUNY Buffalo, Buffalo, NY, USA


9:45 - 10:30 AM

Clinical Examples to Showcase the Disposition Properties of Biologics

Bernd Meibohm, University of Tennessee Health Science Center, Memphis, TN, USA

 

10:30-10:45 AM

Break

 

10:45 - 11:30 AM

Overview - Bioanalytical Methods used to Assess the Disposition of Biologics:

Renuka Pillutla, BMS, Princeton, NJ, USA

 

11:30 - 12:15 PM

Assessing Whole-body Disposition of Biologics (Preclinical and Clinical) using Imaging Method

Andrew Boswell, Genentech, San Francisco, CA, USA

 

12:15-1:30 PM

Lunch Break

 

1:30 - 2:15 PM

Factors Affecting Disposition of Biologics (e.g. TMDD/Immunogenicity/Physicochemical Properties)

Edit Tarcsa, AbbvieBoston, MA, USA

 

2:15 -3:00 PM

DDI Potential of Biologics and Disposition in Special Population

Honghui Zhou, Janssen, Princeton, NJ, USA

 

3:00 - 3:15 PM

Break

 

3:15 - 4:00 PM

Quantitative Characterization and Prediction of the Disposition of Biologics

Dhaval Shah, SUNY Buffalo, Buffalo, NY, USA

 

4:00 - 4:45 PM

Employing the Knowledge about the Disposition of Biologics to Support Discovery, Development, and Clinical Translation

Weirong Wang, Janssen, Springhouse, PA, USA

  

Friday, December 13, 2019

 9:00-9:30 AM

Case Study 1: Understanding the Disposition of Biologics to Treat Neurodegenerative Diseases

Ivan Nestorov, BiogenBoston, MA, USA

 

9:30 - 10:00 AM

Case Study 2: Understanding the Disposition Secukinumab using Skin Microdialysis Studies

 

10:00 - 10:30 AM

Case Study 3: Understanding the Disposition Daratumumab

Thomas Puchalski, JanssenPhiladelphia, PA, USA

 

10:30 - 10:45 AM

Break

 

10:45 - 11:15 AM

Case Sudy 4: Understanding the Disposition Vedolizumab

Maria Rosario, Takeda, San Diego, CA, USA

 

11:15 - 11:45 AM

Role of Biopsy and other Methods to Understand Clinical Disposition of Biologics

 

11:45 - 12:15 PM

Novel in vitro Techniques to Predict the Disposition of Biologics

Dan Rock, Amgen, San Francisco, CA, USA

 

12:15 - 1:30 PM

Lunch Break

 

1:30 - 2:15 PM

Understanding the Disposition of CAR-T and other Engineered Cells

 

2:15 - 3:00 PM

Understanding the Disposition of Oligonucleotides/SiRNA

 

3:00 - 3:15 PM

Break

 

3:15 - 4:00 PM

Understanding the Disposition of Gene Therapy Vectors (e.g. AAV)

Nagendra Chemuturi,  NovartisSeattle, WA, USA

 

4:00 - 4:45 PM

Understanding the Novel Disposition of Novel Immunotherapy Like Oncolytic Virus

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