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Biotransformation in the Context of Drug Design
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Biotransformation in the Context of Drug Design: Steps Taken to Enhance Drug Properties
Presented by: S. Cyrus Khojasteh, Ph.D., Genentech
Friday, July 17, 2020

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Biotransformation (drug metabolism) is one of the main mechanisms used by the body to eliminate drugs. As drug molecules become more complicated, the involvement of diverse drug-metabolizing enzymes increases from P450, UGT, aldehyde oxidase, and beyond. Here we will use our understanding of drug metabolism to enable optimizing and designing drugs.  We will discuss available techniques to think through solving metabolism-issues from rates of metabolism to bioactivation.

About the Speaker:

   S. Cyrus Khojasteh heads the Biotransformation Function at Genentech (South San Francisco). His research focuses on the mechanisms of biotransformation in drug discovery and development, from small molecules, antibody-drug conjugates, and macrocyclic peptides. Cyrus received his Ph.D. in Medicinal Chemistry from the University of Washington under the direction of Dr. Sidney D. Nelson.