Online Store https://www.issx.org/store/ Fri, 26 Apr 2024 05:56:57 GMT Tue, 9 Nov 2021 04:00:00 GMT Copyright © 2021 International Society for the Study of Xenobiotics Recording: Ozanimod Metabolism – Qualification of Disproportionate Metabolites https://www.issx.org/store/viewproduct.aspx?id=17482383 https://www.issx.org/store/viewproduct.aspx?id=17482383 ISSX Webinar Recording and Slides: Ozanimod Metabolism – Qualification of Disproportionate Metabolites

Presented by Sekhar Surapaneni, Ph.D.

Presented October 1, 2020

Product Details:

When you purchase this webinar recording, you will receive a PDF document with a link to the webinar recording as well as the slides presented. Please note that these slides and the recording may not be distributed or duplicated without express permission from the speaker and ISSX. If you have any questions, please contact ISSX at information@issx.org. 

Abstract:

Ozanimod is a once-daily oral immunomodulator that selectively targets sphingosine 1-phosphate 1 (S1P1) and S1P5 and is approved in the US and EU for the treatment of relapsing forms of multiple sclerosis. Full characterization of drug metabolic pathways and enzymes involved in metabolism is important for understanding clinical safety and efficacy profile of the molecule. In vitro and in vivo studies were conducted to characterize the metabolism and identify the pathways and enzymes involved in the metabolism. The unique metabolic aspects of Ozanimod and characterization and qualification of disproportionate metabolites in safety species will be discussed.

About the Speaker:

 

Sekhar Surapaneniis currently Vice President, Nonclinical Disposition and Bioanalysis with BMS and his group is responsible for conducting all drug metabolism and bioanalytical studies in support of drug development for small molecules, biologics and cellular therapies. Prior to joining BMS, he gained about 25 years of experience in drug metabolism and pharmacokinetics area working at Lilly, Abbott, Amgen and Celgene. He received undergraduate training in Pharmacy from BITS, Pilani, India, and PhD in Pharmaceutical Sciences from North Dakota State University.


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DMPK publishes original and innovative scientific papers that address topics broadly related to xenobiotics. The term xenobiotic includes medicinal as well as environmental and agricultural chemicals and macromolecules. The journal is organized into sections as follows:
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